Journal of Medicinal Chemistry
Volume 40, Issue 9 (April 25, 1997)
Copyright © 1997 American Chemical Society

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1293-1315

Pharmacological Options in the Treatment of Benign Prostatic Hyperplasia Barry Kenny, Stephen Ballard, Julian Blagg, and David Fox [Full Article - PDF]

1316-1326

Modeling, Chemistry, and Biology of the Benzolactam Analogues of Indolactam V (ILV). 2. Identification of the Binding Site of the Benzolactams in the CRD2 Activator-Binding Domain of PKC and Discovery of an ILV Analogue of Improved Isozyme Selectivity Alan P. Kozikowski, Shaomeng Wang, Dawei Ma, Jiangchao Yao, Shakeel Ahmad, Robert I. Glazer, Krisztina Bogi, Peter Acs, Shayan Modarres, Nancy E. Lewin, and Peter M. Blumberg [Full Article - PDF]

1327-1339

Studies of Pyrrolo[1,2-a]benzimidazolequinone DT-Diaphorase Substrate Activity, Topoisomerase II Inhibition Activity, and DNA Reductive Alkylation Edward B. Skibo, Samantha Gordon, Laura Bess, Romesh Boruah, and Matthew J. Heileman [Full Article - PDF]

1340-1346

Quantitative Structure-Activity Relationships among Macrolide Antibacterial Agents: In Vitro and in Vivo Potency against Pasteurella multocida James W. McFarland, Cynthia M. Berger, Susan A. Froshauer, Shigeru F. Hayashi, Scott J. Hecker, Burton H. Jaynes, Martin R. Jefson, Barbara J. Kamicker, Christopher A. Lipinski, Kristin M. Lundy, Catherine P. Reese, and Chi B. Vu [Full Article - PDF]

1347-1365

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib) Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw, Jeffery S. Carter, Paul W. Collins, Stephen Docter, Matthew J. Graneto, Len F. Lee, James W. Malecha, Julie M. Miyashiro, Roland S. Rogers, D. J. Rogier, Stella S. Yu, Gary D. Anderson, Earl G. Burton, J. Nita Cogburn, Susan A. Gregory, Carol M. Koboldt, William E. Perkins, Karen Seibert, Amy W. Veenhuizen, Yan Y. Zhang, and Peter C. Isakson [Full Article - PDF]

1366-1372

Synthesis and Ligand Binding of Nortropane Derivatives: N-Substituted 2-Carbomethoxy-3-(4'-iodophenyl)nortropane and N-(3-Iodoprop-(2E)-enyl)-2-carbomethoxy-3-(3',4'-disubstituted phenyl)nortropane. New High-Affinity and Selective Compounds for the Dopamine Transporter Patrick Emond, Lucette Garreau, Sylvie Chalon, Miriam Boazi, Mireille Caillet, Jacques Bricard, Yves Frangin, Laurent Mauclaire, Jean-Claude Besnard, and Denis Guilloteau [Full Article - PDF]

1373-1380

Bioactivities and Secondary Structures of Constrained Analogues of Human Parathyroid Hormone: Cyclic Lactams of the Receptor Binding Region Jean-René Barbier, Witold Neugebauer, Paul Morley, Virginia Ross, Mark Soska, James F. Whitfield, and Gordon Willick [Full Article - PDF]

1381-1390

Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Drugs Bronwyn G. Siim, Graham J. Atwell, Robert F. Anderson, Peter Wardman, Susan M. Pullen, William R. Wilson, and William A. Denny [Full Article - PDF]

1391-1395

Enantioselective Synthesis and Antiproliferative Properties of an Ilmofosine Analog, 2'-(Trimethylammonio)ethyl 3-(Hexadecyloxy)-2-(methoxymethyl)propyl Phosphate, on Epithelial Cancer Cell Growth Robert Bittman, Hoe-Sup Byun, Kasireddy Chandraprakash Reddy, Pranati Samadder, and Gilbert Arthur [Full Article - PDF]

1396-1400

Antimalarial Activity of New Dihydroartemisinin Derivatives. 7. 4-(p-Substituted phenyl)-4(R or S)-[10( or )-dihydroartemisininoxy]butyric Acids1-6 Ai J. Lin, Akram B. Zikry, and Dennis E. Kyle [Full Article - PDF]

1401-1406

Carbocyclic Oxetanocins Lacking the C-3' Methylene Jayu Wu, Stewart W. Schneller, and Katherine L. Seley , Robert Snoeck, Graciela Andrei, Jan Balzarini, and Erik De Clercq [Full Article - PDF]